- Vitanics –HP, -LP, -AO
- 领先世界的纳米技术的创新:
用于化妆品和药品的抗氧化维他命E诱导体
- Vitanics 9(常压纳米乳化剂, In vivo抗氧化剂,皮肤柔和剂)
- Vitanics是一种抗氧化的两性分子物质，由-HP, -LP, -AO 3群构成。Vitanics是一种抗氧化维他命E的非离子性诱导体的in vivo抗氧化两性分子物质，是一种具有表面活性剂、皮肤保护剂、抗氧化剂、皮肤柔和剂等多种功能的生理活性物质。作为一种表面活性剂，其特性是在常压Θ-Point条件下几乎不受油状含量的限制，能以较为经济的方法形成纳米乳液和囊泡，也可用作一般的乳化剂、可溶化剂和分散剂等，各原料的特性如下：
- Vitanics-HP
优秀的 O/W 纳米乳化剂, 皮肤保护剂 -
优秀的 O/W 纳米乳化剂Vitanics-HP是一种创新的抗氧化高分子表面活性剂专利产品，它使得化妆品、药品和食品等产业能开发出更多独特的产品，为纳米乳液的创造和优化带来新的可能性。
Vitanics-HP(30/10, 50/20. 70/30. 100/70)作为一种最早被优化的表面活性剂，使得基于纳米乳液、乳液、囊泡、纳米分散、分散和可溶化系统的处方获得了前所未有的提升。
使得纳米乳液有机会开发出更容易更有效的制造方法，通过这种方法获得的纳米乳液具有创新的优良特性。
- Vitanics-LP
优秀的W/O纳米乳化剂, 皮肤保护剂 - Vitanics-LP两性分子物质不仅是一种高效的W/O乳化剂和纳米乳化剂，同时更具有润滑剂、防紫外线、抑制红斑和黑色素生成的作用。
- Vitanics-AO
新型In Vivo抗氧化剂、皮肤保护剂 -
维他命E是一种受欢迎的自由基捕获剂和抗氧化剂。但如果维他命E暴露在氧气、高温和金属离子环境中，则容易引起变质。
而Vitanics-AO由于是一种两性分子物质，在一般的条件下不会发生变质，特别是在维他命E由于其他成份而容易变质的产品中也较稳定，这一特性非常有用。
Vitanics-AO作为一种两性分子物质，能够保护皮肤不受紫外线伤害，抑制红斑和黑色素的生成，不仅具有硫氧化剂的作用，还具有被皮肤深入吸收、 在细胞间发生作用从而起到润滑的效果。
- VITANICS®-HP(n/m): Superior Oil-in Water Nanoemulsifiers
INCI Name: PPG-m Tocophereth-n - VITANICS-HP superior o/w nanoemulsifiers are a novel and innovative patented class of antioxidative polymeric surfactants that open new possibilities for the creation and optimization of nanoemulsion formulations to allow development of unique products for the cosmetic, drug, and food industries. VITANICS-HP superior o/w nanoemulsifiers are produced by polypropoxylation of polyethoxylated vitamin E (tocopherol), resulting in superior-performance antioxidative emulsifiers, vesicle formers, and dispersants. Their efficiency stems from their role in the stabilization of oil droplets and hydrophobic particles against coalescence and/or flocculation, through a mechanism known as steric stabilization by forming epitaxial mesophase layers. So VITANICS-HP (30/10, 50/20, 70/30, 100/70), the first optimized surfactants of this range, can significantly improve formulations based on nanoemulsions, emulsions, vesicles, and nanodispersion systems. VITANICS-HP also open opportunities for easy and efficient manufacturing method of nanoemulsions at 1 atmospheric pressure with excellent stability and large oil phase content, resulting in new and innovatively superior properties..
- VITANICS®-LP(n/m): Superior Water-in-Oil Nanoemulsifiers
- VITANICS-LP amphiphiles act not only as efficient w/o nanoemulsifiers and emulsifiers but also as emollients, and skin protecting agents from UVB-radiation exposure
- VITANICS®-AO(n/m): Novel In Vivo Antioxidants
- Vitamin E is a popular free radical scavenger and antioxidant. However, vitamin E degrades when exposed to oxygen, high temperature and metal ions. VITANICS-AO amphiphiles do not degrade under normal conditions, and are particularly useful in products where the activity of vitamin E might normally be adversely affected by other ingredients in the products.
- VITANICS®-HP Superior O/W Nanoemulsifiers
Major Benefits: Superior Productivity and Quality -
Nanoemulsions have become increasingly important as potential vehicles for controlling the delivery of cosmetics, for optimizing the disposition of active ingredients in particular skin layers and for their good stability and moisturizing effect. The preparation of conventional nanoemulsions typically requires a high-pressure homogenizer such as a Microfludizer at 800 to 1,600 atmospheric pressures, relatively high phospholipid concentration and raises skin safety concerns, limiting their practical applications in cosmetics and drugs. O/W nanoemulsions prepared using a high-pressure homogenizer usually cannot contain more than 20% oil phase content, limiting formulations can be handled.
VITANICS-HP superior o/w nanoemulsifiers allow preparation of innovative creams and very low viscosity nanoemulsions in the size range of 70-200 nm with only 2-3% emulsifier content and oil phase content up to 80% at 1 atmospheric pressure by simple high-speed stirring.
VITANICS-HP superior o/w nanoemulsifiers can also be used as solubilizers, dispersing agents and gelling agents.
VITANICS®-LP Superior W/O Nanoemulsifiers
Major Benefits: Superior Productivity and Antioxidative Protection of Skin and Hair
- VITANICS®-AO Novel In Vivo Antioxidants
Major Benefits: Protection of Skin by Depressing Erythema Development and Prevention of Skin from Melanin Formations - When VITANICS-AO amphiphiles were applied on human skin before and after UVB-irradiation respectively, they showed significant skin protecting effects by depressing erythema development and preventing skin from melanin formation. This proves that VITANICS-AO has antioxidative activities and/or anti-inflammation effects. VITANICS-AO is considered to have significant free radical scavenging effects against singlet oxygen.
- ▶ About Vitamin E
- It is well known that vitamin E has the following characteristics.
- 1. Provide antioxidant protection to the skin and hair
- 2. Protection against UV-radiation
- 3. Anti-inflammatory effects
- 4. Positive effects in wound healing
- 5. Favorable effects on sebum reduction and acne
- 6. Moisturizing properties
- 7. Liquid crystal formation
- ▶ Specification of VITANICS-A),-LP,-HP (n/m)
-
Characteristic VITANICS AO
(0/5)/(0/10)LP
(5/20)/(10/50)HP
(30/10)/(50/20)HP(70/30)/
(100/70)Appearance at 25℃ Yellow liquid Yellow liquid Yellow soft solid Yellow soft solid *HLB value, calculated -3.1/-3.8 ?2.3/-5.3 6.8/12.5 18.0/24.0 Surface tension at 10-3 mol/l -/- -/- 47/48
dyne/cm53/54
dyne/cmCMC-3mol/l -/- -/- 2.51/1.12 0.8/0.6 Av. Mol. Wt. 719/1,009 1,809/3,769 2,329/3,789 5,249/8,889 - Ash (450-500℃, steady state), %---------------0.2 max.
- Volatile materials (105℃, 1hr), %---------------1.0 max
- Heavy metals, ppm----------------------------20.0 max.
- Arsenics (as As2O3), ppm---------------------2.0 max.
- Moisture, %----------------------------------0.5 max
- *HLB values: Davis, J.T. Proc. 2nd Int. Cong. Surface Activity, London, 1, 426, (1957)
- ▶ Bibliography
- The 17th IFSCC Congress Proceedings, Yokohama, 1992
- The 21st IFSCC Congress Proceedings, Berlin 2000
- The 22nd IFSCC Congress Proceedings, Edinburgh 2002
- The 3rd World Congress on Emulsions Proceedings, Lyon 2002
- The 23rd IFSCC Congress Proceedings, Orlando 2004
- Macromol. Symp. 118, 631-640, 1997
- IFSCC Magazine 4, 4, 269-276, 2001
- Macromol Rapid Commun. 19, 27-30, 1998,
- C & T 103, 63-78, 1993
- Y-D Kim’s Ph. D. Thesis, Tocopherol-Containing Polymeric Vesicles, KAIST Korea, 1998
- IFSCC Magazine vol. 7, no. 4 219-225 October/December 2004,
- April 2006, Patent ROK No. 623013 was selected as an International Patent (PCT) Charge ($5,500) Supporting Patent by the Korea Health Industry Developing Institute
- February 2007, Nanoemulsion, The Use Thereof and Method Thereof Patent Pending EP No. 5781134.1
- March 2007, Nanoemulsion, The Use Thereof and Method Thereof Patent Pending USA No. 11/682279
- March 2007, Nanoemulsion, The Use Thereof and Method Thereof Patent Pending China No. 200580033218.6
- August 2007, Patent ROK No. 0623013 was selected as an Evaluation Supporting Patent by KIPI and granted $25,000 of evaluation supporting funds.
- October 2007, The technological and business value of Patent ROK No. 062013 evaluated by the Korea Technology Transfer Center and supported by the KIPI was $4.1 million and $7 million, respectively.
- October 2007, The technological and business value of Patent ROK No. 062013 evaluated by the Korea Technology Transfer Center and supported by the KIPI was $4.1 million and $7 million, respectively.
- October 2008, Presented a nanoemulsion paper at the 25th IFSCC Congress Barcelona, Spain February 2008, Quality Management System Certificate No. KorQ-082436, ISO 9001: 2000
- ▶ VITANICS所获专利、认证及奖项
- 国际物质专利：韩国、美国、英国、法国、德国、意大利、西班牙、日本、中国、巴西、印度、墨西哥等12个国家
- 韩国新技术认证（2002-027号）：抗氧化纳米维生素E衍生物制备技术（2007年7月11日）
- 德国柏林第21届国际化妆品化学家学会联盟（IFSCC Congress）韩国唯一发表口头论文企业（2000年9月14-17日）
- 苏格兰爱丁堡第22届国际化妆品化学家学会联盟发表纳米乳液研究论文（2002年10月14-17日）
- 法国里昂第3届化工展（World Congress on Emulsion）发表研究论文（2002年10月10-13日）
- 美国奥兰多第23届国际化妆品化学家学会联盟发表纳米乳液制备方法研究论文（2004年10月24-28日）
- 国际化妆品化学家学会联盟的正式学术刊物——IFSCC Magazine韩国首次刊载论文（vol 4. no 4，2001年）
- 国际化妆品化学家学会联盟的正式学术刊物——IFSCC Magazine刊载新纳米乳液制备方法论文（vol 7. no 4，2004年）
- VITANICS登载于美国化妆品香料香精协会（CTFA）发刊的国际化妆品原料词典（ICID）和手册（2001年，10月16日）
- 2005年韩国纳米技术展览会（Nano Korea 2005）、第3届国际纳米科技大会及展览会荣获纳米领域技术奖（组织委员长奖）（2005年，8月24日）
- 2005年韩国技术大展（NEWTECH KOREA 2005）荣获产业资源部长官奖（优秀奖）（2005年10月20日）
- 2006年04月 获选韩国保健产业振兴院专利费支援项目，荣获550万韩元的PCT申请费用
- 2007年02月 申请纳米乳液用途及其制备方法专利（欧洲5781134.1号）
- 2007年03月 申请纳米乳液用途及其制备方法专利（美国11/682279号）
- 2007年03月 申请纳米乳液用途及其制备方法专利（中国200580033218.6号）
- 2007年08月 发明专利第0623013号，获得韩国发明振兴院评估资金援助专利（2500万韩元)
- 2007年10月 发表VITANICS常压Θ-point纳米乳液制备研究论文（西班牙巴塞罗那第25届国际化妆品化学家学会联盟，2008年）
- 2007年10月 纳米乳液用途及其制备方法专利（韩国623013号）技术价值和营业价值获得韩国技术交易所分别评估为41亿韩元和70亿韩元
- 2008年02月 质量管理系统认证号第KorQ-082436号，ISO 9001: 2000
- 2004年、2005年、2008年03月 获得中小企业厅3次评选为“出口型企业”，并取得3000万韩元资金援助
- 2010年10月 荣获韩国发明专利大展铜奖